Targeting EHMT2 overcomes 5-fluorouracil resistance in colorectal cancer by modulating cell cycle and apoptosis

Abstract 5-Fluorouracil (5-FU) is a first-line chemotherapy commonly used to treat colorectal cancer (CRC). However, the development of acquired resistance to 5-FU remains a significant clinical challenge, and the underlying epigenetic mechanisms are not fully understood. In this study, we demonstra...

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Detalles Bibliográficos

Principais autores:	In Hwan Tae, Yunsang Kang, Jinkwon Lee, Jeong Min Lee, Jinsan Kim, Su-gi Lee, Kunhyang Park, Tae Young Ryu, Kwangho Kim, Gyeonghwa Kim, Taesang Son, Hye Won Lee, Solbi Kim, Hyo Jin Lee, Cho-Rok Jung, Jung Hwa Lim, Moo-Seung Lee, Keun Hur, Tae-Su Han, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2026-05-01
Series:	Signal Transduction and Targeted Therapy
Acceso en liña:	https://doi.org/10.1038/s41392-026-02692-7
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