Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats
The frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme responsible for the synthesis of renal vasodilator prostaglandins, while COX-2 participates predominantl...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Associação Brasileira de Divulgação Científica
2004-01-01
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| Serija: | Brazilian Journal of Medical and Biological Research |
| Teme: | |
| Online dostop: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700006 |
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