Pharmacokinetic Models to Characterize the Absorption Phase and the Influence of a Proton Pump Inhibitor on the Overall Exposure of Dacomitinib

Introduction: Dacomitinib is an epidermal growth factor receptor (EGFR) inhibitor approved for the treatment of metastatic non-small cell lung cancer (NSCLC) in the first line in patients with EGFR activating mutations. Dacomitinib is taken orally once daily at 45 mg with or without food, until dise...

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Detalhes bibliográficos

Principais autores:	Ana Ruiz-Garcia, Weiwei Tan, Jerry Li, May Haughey, Joanna Masters, Jennifer Hibma, Swan Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-04-01
coleção:	Pharmaceutics
Assuntos:	zero-order absorption first-order absorption combined zero- and first-order absorption transit compartment absorption model
Acesso em linha:	https://www.mdpi.com/1999-4923/12/4/330
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