DNMT3A-R882 mutation promotes acute myeloid leukemia progression by recruiting E2H2 to inhibit circKCNQ5 methylation

Abstract Background Patients with acute myeloid leukemia (AML) harboring the DNMT3A-R882 mutation (DR882MUT) are often more difficult to treat and more likely to relapse. However, whether DR882MUT modulates AML progression via circRNAs remains unknown. Methods Bioinformatics was used to assess the a...

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Principais autores:	Yijian Chen, Xiaodan Zhu, Chuanming Lin, Rong Xu, Pengxiang Xu, Liuyan Xin, Lin Li, Liqun Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer 2025-09-01
Serija:	Discover Oncology
Teme:	AML DNMT3A R882 mutation circKCNQ5 Proliferation Apoptosis Methylation
Online dostop:	https://doi.org/10.1007/s12672-025-03347-9
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