MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling

Abstract The incidence of cutaneous melanoma (CM) has been increasing annually worldwide. In this study, we identify that MrgprF, a MAS related GPR family member, is decreased in cutaneous melanoma tissues and cell lines due to hypermethylation of its promoter region, and show that patients with CM...

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Detalhes bibliográficos

Principais autores:	Qiushuo Shen, Yanfei Han, Kai Wu, Yaomei He, Xiulin Jiang, Peishen Liu, Cuifeng Xia, Qiuxia Xiong, Rui Liu, Qianming Chen, Yong Zhang, Song Zhao, Cuiping Yang, Yongbin Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2022-05-01
coleção:	Signal Transduction and Targeted Therapy
Acesso em linha:	https://doi.org/10.1038/s41392-022-00945-9
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