Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists

This study explored the potential of a series of PZM21 analogues for pain treatment. Specifically, the hydroxyphenyl ring of PZM21 was replaced with a naphthyl ring, the thienyl ring was substituted with either a phenyl ring or furan rings, and the essential dimethylamine and urea groups were retain...

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Bibliographic Details

Main Authors:	Yanhao Guo, Ruimin Yu, Tao Zhang, Fengxia Ren, Zixing Yu, Jingchao Cheng, Hongxin Jia, Weiguo Shi, Yatong Zhang
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2024-06-01
Series:	Molecules
Subjects:	µOR-biased agonist PZM21 safer opioids β-arrestin-2 recruitment structure activity relationship
Online Access:	https://www.mdpi.com/1420-3049/29/13/2961
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