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Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists

This study explored the potential of a series of PZM21 analogues for pain treatment. Specifically, the hydroxyphenyl ring of PZM21 was replaced with a naphthyl ring, the thienyl ring was substituted with either a phenyl ring or furan rings, and the essential dimethylamine and urea groups were retain...

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Bibliográfalaš dieđut
Váldodahkkit: Yanhao Guo, Ruimin Yu, Tao Zhang, Fengxia Ren, Zixing Yu, Jingchao Cheng, Hongxin Jia, Weiguo Shi, Yatong Zhang
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: MDPI AG 2024-06-01
Ráidu:Molecules
Fáttát:
Liŋkkat:https://www.mdpi.com/1420-3049/29/13/2961
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