RANKL–RANK signaling promotes cigarette smoke–induced emphysema with MMP-9 upregulation in alveolar macrophages

BackgroundChronic obstructive pulmonary disease (COPD) is a leading global health problem, with pulmonary emphysema as one of its hallmark pathological features. Matrix metalloproteinase-9 (MMP-9), predominantly derived from alveolar macrophages, has been implicated in extracellular matrix degradati...

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Autors principals:	Lu Zhou, Baiquan Zhang, Huanqin Wang, Fengxiang Huang, Lijun Miao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-06-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	alveolar macrophages COPD emphysema MMP-9 RANKL
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1754836/full
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