PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise

Phosphodiesterase 1B (PDE1B) and phosphodiesterase 10A (PDE10A), members of the phosphodiesterase superfamily, are responsible for cyclic nucleotide hydrolysis, thereby regulating key intracellular signaling pathways such as cAMP response element-binding protein (CREB) activation and brain-derived n...

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Hlavní autoři:	Jaya Rautela, Anand Gaurav, Veeranoot Nissapatorn, Chung Keat Tan, Ana Paula Girol, Maria De Lourdes Pereira, Vannajan Sanghiran Lee
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-02-01
Edice:	Frontiers in Pharmacology
Témata:	clinical transition dual inhibitors phosphodiesterase 10A phosphodiesterase 1B schizophrenia
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1735760/full
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