PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise

Phosphodiesterase 1B (PDE1B) and phosphodiesterase 10A (PDE10A), members of the phosphodiesterase superfamily, are responsible for cyclic nucleotide hydrolysis, thereby regulating key intracellular signaling pathways such as cAMP response element-binding protein (CREB) activation and brain-derived n...

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Principais autores:	Jaya Rautela, Anand Gaurav, Veeranoot Nissapatorn, Chung Keat Tan, Ana Paula Girol, Maria De Lourdes Pereira, Vannajan Sanghiran Lee
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2026-02-01
סדרה:	Frontiers in Pharmacology
נושאים:	clinical transition dual inhibitors phosphodiesterase 10A phosphodiesterase 1B schizophrenia
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1735760/full
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!