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FUT11-Driven fucosylation coordinates K63 ubiquitination of keratin 17 to sustain psoriatic keratinocytes hyperproliferation

Abstract Background The pathogenesis of psoriasis is characterized by dysregulated post-translational modifications, with particular emphasis on fucosylation—a glycosylation process mediated by fucosyltransferases (FUTs). Keratin 17 (K17), overexpressed in psoriatic keratinocytes, drives inflammatio...

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Principais autores: Xia Li, Guohao Li, Haijun Miao, Lixin Yue, Jixin Gao, Qingyang Li, Shuai Shao, Gang Wang, Erle Dang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-10-01
Serier:Cell Communication and Signaling
Fag:
Fucosylation
Fucosyltransferase 11 (FUT11)
Psoriasis
Keratinocytes
Proliferation
Ubiquitination
Online adgang:https://doi.org/10.1186/s12964-025-02422-6
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