FUT11-Driven fucosylation coordinates K63 ubiquitination of keratin 17 to sustain psoriatic keratinocytes hyperproliferation

Abstract Background The pathogenesis of psoriasis is characterized by dysregulated post-translational modifications, with particular emphasis on fucosylation—a glycosylation process mediated by fucosyltransferases (FUTs). Keratin 17 (K17), overexpressed in psoriatic keratinocytes, drives inflammatio...

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Bibliographic Details

Main Authors:	Xia Li, Guohao Li, Haijun Miao, Lixin Yue, Jixin Gao, Qingyang Li, Shuai Shao, Gang Wang, Erle Dang
Format:	Artigo
Language:	Inglês
Published:	BMC 2025-10-01
Series:	Cell Communication and Signaling
Subjects:	Fucosylation Fucosyltransferase 11 (FUT11) Psoriasis Keratinocytes Proliferation Ubiquitination
Online Access:	https://doi.org/10.1186/s12964-025-02422-6
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