Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes.
Complex diseases are often highly heritable. However, for many complex traits only a small proportion of the heritability can be explained by observed genetic variants in traditional genome-wide association (GWA) studies. Moreover, for some of those traits few significant SNPs have been identified....
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science (PLoS)
2011-01-01
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| Серии: | PLoS ONE |
| Online-ссылка: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22140493/?tool=EBI |
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