Evaluation of neurotoxicity of drugs from morphological and electrophysiological endpoints using human iPSC-derived neural cell models

IntroductionGenome-edited human induced pluripotent stem cells (iPSCs) were first generated in 2007, and have been applied in pharmaceutical research, development, and clinical therapy as an in vitro platform for personalised phenotyping and drug discovery. iPSCs can differentiate into multiple type...

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Päätekijät:	Zhe Qu, Shuangxing Li, Jingru Qiu, Guitao Huo, YuLin Liu, Di Zhang, Yanwei Yang, Xingchao Geng, Zhi Lin
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2026-02-01
Sarja:	Frontiers in Cellular and Infection Microbiology
Aiheet:	electrophysiological activity high-content imaging hiPSC-derived neural cells microelectrode array detection neurite outgrowth neurotoxicity
Linkit:	https://www.frontiersin.org/articles/10.3389/fcimb.2026.1728941/full
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