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Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor

Abstract Background Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. However, these noncanonical redox cofactors need to be biologically synthesiz...

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Main Authors: William B. Black, Derek Aspacio, Danielle Bever, Edward King, Linyue Zhang, Han Li
Format: Artigo
Language:Inglês
Published: BMC 2020-07-01
Series:Microbial Cell Factories
Subjects:
Nicotinamide mononucleotide
Noncanonical redox cofactor
Escherichia coli
Metabolic engineering
NAD+ biosynthesis
Biomimetic cofactor
Online Access:http://link.springer.com/article/10.1186/s12934-020-01415-z
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