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Distinct cMET inhibitors uncover pharmacological heterogeneity in SHH medulloblastoma cell lines

Abstract The c-MET kinase signalling pathway is crucial in cerebellum development and has emerged as a potential therapeutic target for medulloblastoma treatment. Our study confirms that c-MET and its ligand HGF are highly expressed in the SHH medulloblastoma subgroup, with SHH-α and SHH-β subtypes...

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Hlavní autoři: Sonia Morlando, Alexander W. I. Cox, Aabha Mahesh Thite, Ruth Aidoo, James Wilkinson, Caroline H. Topham, Gianpiero Di Leva
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer 2026-02-01
Edice:Discover Oncology
On-line přístup:https://doi.org/10.1007/s12672-026-04717-7
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