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Dominant drug targets suppress the emergence of antiviral resistance

The emergence of drug resistance can defeat the successful treatment of pathogens that display high mutation rates, as exemplified by RNA viruses. Here we detail a new paradigm in which a single compound directed against a ‘dominant drug target’ suppresses the emergence of naturally occurring drug-r...

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Bibliografiske detaljer
Principais autores: Elizabeth J Tanner, Hong-mei Liu, M Steven Oberste, Mark Pallansch, Marc S Collett, Karla Kirkegaard
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2014-11-01
Serier:eLife
Fag:
Online adgang:https://elifesciences.org/articles/03830
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