The HSV-1 ICP4 Transcriptional Auto-Repression Circuit Functions as a Transcriptional “Accelerator” Circuit

Herpes simplex virus-1 (HSV-1) is a significant human pathogen. Upon infection, HSV-1 expresses its immediate early (IE) genes, and the IE transcription factor ICP4 (infectious cell protein-4) plays a pivotal role in initiating the downstream gene-expression cascade. Using live-cell time-lapse fluor...

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Bibliografski detalji

Glavni autori:	Sonali Chaturvedi, Ruth Engel, Leor Weinberger
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2020-06-01
Serija:	Frontiers in Cellular and Infection Microbiology
Teme:	herpesvirus single-cell time-lapse imaging fitness advantage accelerator circuit autoregulation transcriptional feedback
Online pristup:	https://www.frontiersin.org/article/10.3389/fcimb.2020.00265/full
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