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Beyond the Mutation Abyss: Revisiting SARS-CoV-2 Receptor-Binding Domain Evolution from ACE2 Binding Optimization to Immune Epitope Remodeling

The SARS-CoV-2 Omicron variant and its descendants accumulated unprecedented numbers of spike substitutions yet remained transmissible, implying compensatory mechanisms that preserve entry while eroding humoral immunity. We analyzed 32 variants for sequence-level mutation, physicochemical profiling,...

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Principais autores: Omar A. Soliman, Yasmine Shahine, Daniel Baecker, Ahmed Noby Amer
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Pathogens
Fag:
SARS-CoV-2
Omicron
receptor-binding domain
immune escape
epitope conservation
antigenic drift
Online adgang:https://www.mdpi.com/2076-0817/15/3/272
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