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Glavonoid, a possible supplement for prevention of ATTR amyloidosis

Transthyretin (TTR) is an amyloidogenic protein associated with hereditary and nonhereditary transthyretin amyloidoses (ATTR). Dissociation of the tetramer of TTR to the monomer induces TTR misfolding, which leads to amyloid fibril formation and triggers the onset of ATTR amyloidosis. Stabilizers of...

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Main Authors: Hiroaki Matsushita, Aito Isoguchi, Masamitsu Okada, Teruaki Masuda, Yohei Misumi, Chiharu Tsutsui, Narumi Yamaguchi, Yuko Ichiki, Jinko Sawashita, Mitsuharu Ueda, Mineyuki Mizuguchi, Yukio Ando
Format: Artigo
Language:Inglês
Published: Elsevier 2021-10-01
Series:Heliyon
Subjects:
TTR
Glavonoid
Glabridin
Amyloidosis
Tetramer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021022040
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