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Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder that manifests sequential Aβ and tau brain pathology with age-dependent onset. Variants in the microglial immune receptor TREM2 are associated with enhanced risk of onset in sporadic Alzheimer’s disease (AD). While recent s...

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Autori principali: Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y. Huang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2022-09-01
Serie:Molecular Neurodegeneration
Soggetti:
Trem2
Microglia
Exosomes
Tau pathology
Tau spreading
Alzheimer’s disease
Accesso online:https://doi.org/10.1186/s13024-022-00562-8
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