Mechanisms of Pertussis Toxin Action: ADP-Ribosylation and Its Role in Pertussis Pathogenesis
Pertussis toxin (PTx) is a major virulence factor of <i>Bordetella pertussis</i> and an AB5-type exotoxin that disrupts host signaling. Its enzymatic A subunit ADP-ribosylates the α-subunit of inhibitory G proteins (Gα<sub>i</sub>), preventing them from mediating receptor-induced inhibition of adeny...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI AG
2026-03-01
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| Col·lecció: | Toxins |
| Matèries: | |
| Accés en línia: | https://www.mdpi.com/2072-6651/18/3/148 |
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