In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds

The GABAB receptor (GABAB-R) is a heterodimeric class C G protein-coupled receptor comprised of the GABAB1a/b and GABAB2 subunits. The endogenous orthosteric agonist γ-amino-butyric acid (GABA) binds within the extracellular Venus flytrap (VFT) domain of the GABAB1a/b subunit. The receptor is...

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Principais autores:	Linn M. Evenseth, Dawid Warszycki, Andrzej J. Bojarski, Mari Gabrielsen, Ingebrigt Sylte
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2019-03-01
丛编:	Molecules
主题:	GABAB receptor orthosteric binding site virtual screening ligand-based screening structure-based screening
在线阅读:	http://www.mdpi.com/1420-3049/24/5/935
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