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JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice

Type 2 diabetes mellitus (T2DM) arises primarily due to lifestyle factors and genetics. A number of lifestyle factors are known to be important in the development of T2DM, including obesity. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase 1 inhibitor, reduced body weight depending on dietar...

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Autori principali: Daisuke Tomimoto, Chihiro Okuma, Yukihito Ishii, Akio Kobayashi, Takeshi Ohta, Makoto Kakutani, Tsuneo Imanaka, Nobuya Ogawa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015-09-01
Serie:Journal of Pharmacological Sciences
Soggetti:
Obesity
Type 2 diabetes
Insulin resistance
Triacylglycerol
Acyl CoA:diacylglycerol acyltransferase (DGAT) 1
Accesso online:http://www.sciencedirect.com/science/article/pii/S1347861315001802
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