DCI-SiteDTA: drug-target affinity prediction based on binding sites detection and site-aware dual cross-interaction block

Abstract Background Predicting the binding affinity between drugs and proteins is crucial for accelerating drug discovery. However, traditional research methods typically treat binding site detection and affinity prediction as two separate tasks, lacking solutions that integrate both into a unified...

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Autors principals:	Jinyang Zhang, Xingyang Li, Bo Wei, Yuni Zeng
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-04-01
Col·lecció:	BMC Bioinformatics
Matèries:	Drug-target affinity Deep learning Binding site detection Multi-scale feature fusion
Accés en línia:	https://doi.org/10.1186/s12859-026-06446-8
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