Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels

IntroductionClassically activated innate immune cells undergo a metabolic switch to aerobic glycolysis to support effector function. We report that the small-molecule nitroalkene 10-n-octadec-9-enoic acid (NO2-OA) attenuates the Warburg- like phenotype of aerobic glycolysis in lipopolysaccharide (LP...

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Detaylı Bibliyografya
Asıl Yazarlar:	Emily R. Stevenson, James P. O’Brien, Allison M. Manuel, Crystal E. Uvalle, Gregory J. Buchan, Steven J. Mullett, Karina Lockwood, Tomeka Suber, Bruce A. Freeman, Stacy L. Gelhaus
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2025-10-01
Seri Bilgileri:	Frontiers in Physiology
Konular:	metabolism inflammation nitroalkene fatty acid glutamine metabolism macrophage
Online Erişim:	https://www.frontiersin.org/articles/10.3389/fphys.2025.1426102/full
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels

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