Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses

Background: Dengue Virus (DENV) associated disease is a major public health problem. Assessment of HLA class II restricted DENV-specific responses is relevant for immunopathology and definition of correlates of protection. While previous studies characterized responses restricted by the HLA-DRB1 loc...

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Autors principals:	Alba Grifoni, Eugene Moore, Hannah Voic, John Sidney, Elizabeth Phillips, Ramesh Jadi, Simon Mallal, Aruna D. De Silva, Aravinda M. De Silva, Bjoern Peters, Daniela Weiskopf, Alessandro Sette
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-07-01
Col·lecció:	Frontiers in Immunology
Matèries:	DENV CD4+T cells HLA-DP HLA-DQ HLA-DRB3/4/5 adaptive immunity
Accés en línia:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01568/full
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