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Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses

Background: Dengue Virus (DENV) associated disease is a major public health problem. Assessment of HLA class II restricted DENV-specific responses is relevant for immunopathology and definition of correlates of protection. While previous studies characterized responses restricted by the HLA-DRB1 loc...

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Principais autores: Alba Grifoni, Eugene Moore, Hannah Voic, John Sidney, Elizabeth Phillips, Ramesh Jadi, Simon Mallal, Aruna D. De Silva, Aravinda M. De Silva, Bjoern Peters, Daniela Weiskopf, Alessandro Sette
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-07-01
coleção:Frontiers in Immunology
Assuntos:
DENV
CD4+T cells
HLA-DP
HLA-DQ
HLA-DRB3/4/5
adaptive immunity
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.01568/full
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