Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
Objective: The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) accumulate with overnutrition and have been implicated in non-alcoholic steatohepatitis (NASH) development. ORMDL3, a negative regulator of the rate-limiting step in ceramide biosynthesis, has been identifie...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2024-01-01
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| シリーズ: | Molecular Metabolism |
| 主題: | |
| オンライン･アクセス: | http://www.sciencedirect.com/science/article/pii/S2212877823001850 |
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