Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis

ORMDL3 is a prominent member of a family of highly conserved endoplasmic reticulum resident proteins, ORMs (ORM1 and ORM2) in yeast, dORMDL in Drosophila and ORMDLs (ORMDL1, ORMDL2, and ORMDL3) in mammals. ORMDL3 mediates feedback inhibition of de novo sphingolipid synthesis. Expression levels of OR...

Full description

Bibliographic Details

Main Authors:	Livia Demkova, Viktor Bugajev, Miroslava K. Adamcova, Ladislav Kuchar, Srdjan Grusanovic, Meritxell Alberich-Jorda, Petr Draber, Ivana Halova
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2024-04-01
Series:	Frontiers in Immunology
Subjects:	lymphocyte B cells sphingolipids ORMDL proteins spleen
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376629/full
Tags:	Add Tag No Tags, Be the first to tag this record!