Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.
Gardado en:
| Principais autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2019-10-01
|
| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-019-12393-1 |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|