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Optimized Protocol to Generate Spinal Motor Neuron Cells from Induced Pluripotent Stem Cells from Charcot Marie Tooth Patients

Modelling rare neurogenetic diseases to develop new therapeutic strategies is highly challenging. The use of human-induced pluripotent stem cells (hiPSCs) is a powerful approach to obtain specialized cells from patients. For hereditary peripheral neuropathies, such as Charcot–Marie–Tooth disease (CM...

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Principais autores: Pierre-Antoine Faye, Nicolas Vedrenne, Federica Miressi, Marion Rassat, Sergii Romanenko, Laurence Richard, Sylvie Bourthoumieu, Benoît Funalot, Franck Sturtz, Frederic Favreau, Anne-Sophie Lia
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-06-01
Serier:Brain Sciences
Fag:
induced pluripotent stem cells
hiPSC
spinal motor neurons
cellular models
peripheral nervous system
Charcot-Marie-Tooth
Online adgang:https://www.mdpi.com/2076-3425/10/7/407
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