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Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining

Abstract Background Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) share many common features, including similar morphology, gene expression and in vitro differentiation profiles. However, genomic stability is much lower in iPSCs than in ESCs. In the current study, we examine...

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Hlavní autoři: Minjie Zhang, Liu Wang, Ke An, Jun Cai, Guochao Li, Caiyun Yang, Huixian Liu, Fengxia Du, Xiao Han, Zilong Zhang, Zitong Zhao, Duanqing Pei, Yuan Long, Xin Xie, Qi Zhou, Yingli Sun
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley 2018-07-01
Edice:Cancer Communications
Témata:
Genomic stability
DNA damage repair
iPSCs
ESCs
On-line přístup:http://link.springer.com/article/10.1186/s40880-018-0313-0
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