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Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation

Long-chain acyl-CoA synthetase (ACSL) 4 converts polyunsaturated fatty acids (PUFAs) into their acyl-CoAs and plays an important role in maintaining PUFA-containing membrane phospholipids. Here we demonstrated decreases in various kinds of PUFA-containing phospholipid species in ACSL4-deficient muri...

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Main Authors: Yuki Tomitsuka, Hiroki Imaeda, Haruka Ito, Isaki Asou, Masayuki Ohbayashi, Fumihiro Ishikawa, Hiroshi Kuwata, Shuntaro Hara
Format: Artigo
Language:Inglês
Published: Elsevier 2023-10-01
Series:Redox Biology
Subjects:
Long-chain acyl-CoA synthetase 4
ACSL4
Paraquat
Methotrexate
Lipid peroxide
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002513
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