Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere
Abstract Rad51 maintains genome integrity, whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs). Here we find that fission yeast Srr1/Ber1 and Skb1/PRMT5 promote GCRs at centromeres. Genetic and physical analyses show that srr1 and skb1 mutat...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Portfolio
2023-05-01
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| Schriftenreihe: | Communications Biology |
| Online-Zugang: | https://doi.org/10.1038/s42003-023-04925-9 |
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