Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere

Abstract Rad51 maintains genome integrity, whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs). Here we find that fission yeast Srr1/Ber1 and Skb1/PRMT5 promote GCRs at centromeres. Genetic and physical analyses show that srr1 and skb1 mutat...

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Detalles Bibliográficos

Principais autores:	Piyusha Mongia, Naoko Toyofuku, Ziyi Pan, Ran Xu, Yakumo Kinoshita, Keitaro Oki, Hiroki Takahashi, Yoshitoshi Ogura, Tetsuya Hayashi, Takuro Nakagawa
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2023-05-01
Series:	Communications Biology
Acceso en liña:	https://doi.org/10.1038/s42003-023-04925-9
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