Development of a Non-Peptide Angiotensin II Type 1 Receptor Ligand by Structural Modification of Olmesartan as a Biased Agonist
As a biased agonist, peptide angiotensin II (Ang II) type 1 (AT<sub>1</sub>) receptor ligand antagonizes Ang II-stimulated G protein signaling but stimulates several kinase pathways. Here, we developed a non-peptide AT<sub>1</sub> receptor compound as a biased ligand. We synthesized three non-peptid...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI AG
2023-05-01
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| Collection: | Biomedicines |
| Sujets: | |
| Accès en ligne: | https://www.mdpi.com/2227-9059/11/5/1486 |
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