Development of a Non-Peptide Angiotensin II Type 1 Receptor Ligand by Structural Modification of Olmesartan as a Biased Agonist

As a biased agonist, peptide angiotensin II (Ang II) type 1 (AT₁) receptor ligand antagonizes Ang II-stimulated G protein signaling but stimulates several kinase pathways. Here, we developed a non-peptide AT₁ receptor compound as a biased ligand. We synthesized three non-peptid...

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Hlavní autoři:	Yoshino Matsuo, Yasunori Suematsu, Hidetaka Morita, Shin-ichiro Miura
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-05-01
Edice:	Biomedicines
Témata:	AT<sub>1</sub> receptor biased ligand inositol phosphate production extracellular signal-regulated kinase
On-line přístup:	https://www.mdpi.com/2227-9059/11/5/1486
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