Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in <i>Candida glabrata</i>

In this study, we have specifically blocked a key step of sphingolipid (SL) biosynthesis in <i>Candida glabrata</i> by disruption of the orthologs of ScIpt1 and ScSkn1. Based on their close homology with <i>S. cerevisiae</i> counterparts, the proteins are predicted to catalyze the addition of a phos...

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Үндсэн зохиолчид:	Garima Shahi, Mohit Kumar, Nitesh Kumar Khandelwal, Atanu Banerjee, Parijat Sarkar, Sonam Kumari, Brooke D. Esquivel, Neeraj Chauhan, Amitabha Chattopadhyay, Theodore C. White, Naseem A. Gaur, Ashutosh Singh, Rajendra Prasad
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2022-06-01
Цуврал:	Journal of Fungi
Нөхцлүүд:	<i>Candida glabrata</i> sphingolipids inositolphosphorylceramide lipidomics drug resistance virulence
Онлайн хандалт:	https://www.mdpi.com/2309-608X/8/7/651
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!