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Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in <i>Candida glabrata</i>

In this study, we have specifically blocked a key step of sphingolipid (SL) biosynthesis in <i>Candida glabrata</i> by disruption of the orthologs of ScIpt1 and ScSkn1. Based on their close homology with <i>S. cerevisiae</i> counterparts, the proteins are predicted to catalyze the addition of a phos...

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Huvudupphov: Garima Shahi, Mohit Kumar, Nitesh Kumar Khandelwal, Atanu Banerjee, Parijat Sarkar, Sonam Kumari, Brooke D. Esquivel, Neeraj Chauhan, Amitabha Chattopadhyay, Theodore C. White, Naseem A. Gaur, Ashutosh Singh, Rajendra Prasad
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2022-06-01
Serie:Journal of Fungi
Ämnen:
<i>Candida glabrata</i>
sphingolipids
inositolphosphorylceramide
lipidomics
drug resistance
virulence
Länkar:https://www.mdpi.com/2309-608X/8/7/651
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