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Proteomics and phosphoproteomics of chordoma biopsies reveal alterations in multiple pathways and aberrant kinases activities

BackgroundChordoma is a slow-growing but malignant subtype of bone sarcoma with relatively high recurrence rates and high resistance to chemotherapy. It is urgent to understand the underlying regulatory networks to determine more effective potential targets. Phosphorylative regulation is currently r...

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Autori principali: Jing Hang, Hanqiang Ouyang, Feng Wei, Qihang Zhong, Wanqiong Yuan, Liang Jiang, Zhongjun Liu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-09-01
Serie:Frontiers in Oncology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2022.941046/full
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