Inactivation of cAMP receptor protein (MSMEG_6189) increases isoniazid susceptibility in Mycobacterium smegmatis via altered oxidative phosphorylation, elevated ROS production, and loss of ahpC expression
ABSTRACT Isoniazid (INH) is a first-line drug for treating drug-susceptible tuberculosis. The genome of Mycobacterium smegmatis encodes two cAMP receptor proteins (Crp), MSMEG_6189 (Crp1) and MSMEG_0539 (Crp2). The deletion of crp1 markedly increased susceptibility to INH, whereas the deletion of cr...
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| Автори: | , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Microbiology
2025-12-01
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| Серія: | Journal of Bacteriology |
| Предмети: | |
| Онлайн доступ: | https://journals.asm.org/doi/10.1128/jb.00429-25 |
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