Inactivation of cAMP receptor protein (MSMEG_6189) increases isoniazid susceptibility in Mycobacterium smegmatis via altered oxidative phosphorylation, elevated ROS production, and loss of ahpC expression

ABSTRACT Isoniazid (INH) is a first-line drug for treating drug-susceptible tuberculosis. The genome of Mycobacterium smegmatis encodes two cAMP receptor proteins (Crp), MSMEG_6189 (Crp1) and MSMEG_0539 (Crp2). The deletion of crp1 markedly increased susceptibility to INH, whereas the deletion of cr...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Narin Kim, Yuna Oh, Jeong-Il Oh
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2025-12-01
Serija:	Journal of Bacteriology
Teme:	AhpC cAMP receptor protein electron transport chain isoniazid KatG Mycobacterium
Online dostop:	https://journals.asm.org/doi/10.1128/jb.00429-25
Oznake:	Označite Brez oznak, prvi označite!