T4 DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR editing

Abstract Unintended on-target chromosomal alterations induced by CRISPR/Cas9 in mammalian cells are common, particularly large deletions and chromosomal translocations, and present a safety challenge for genome editing. Thus, there is still an unmet need to develop safer and more efficient editing t...

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Bibliografski detalji

Glavni autori:	Qiaoyan Yang, Jonathan S Abebe, Michelle Mai, Gabriella Rudy, Sang Y Kim, Orrin Devinsky, Chengzu Long
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2024-07-01
Serija:	The EMBO Journal
Teme:	DNA Polymerase CRISPR/Cas9 On-target Damage DMD T Cell
Online pristup:	https://doi.org/10.1038/s44318-024-00158-6
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