T4 DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR editing
Abstract Unintended on-target chromosomal alterations induced by CRISPR/Cas9 in mammalian cells are common, particularly large deletions and chromosomal translocations, and present a safety challenge for genome editing. Thus, there is still an unmet need to develop safer and more efficient editing t...
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| Автори: | , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Springer Nature
2024-07-01
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| Серія: | The EMBO Journal |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1038/s44318-024-00158-6 |
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