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Efficacy of Oroxylin A in ameliorating renal fibrosis with emphasis on Sirt1 activation and TGF-β/Smad3 pathway modulation

IntroductionRenal fibrosis poses a serious threat to human health. At present, there are few types of traditional Chinese medicine used to treat this disease, and Oroxylin A (OA), as a natural product with multiple biological activities, is expected to be used for the treatment of renal fibrosis.Met...

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Main Authors: Guangzhuang Li, Sentao Xian, Xianchao Cheng, Yunhua Hou, Wenqing Jia, Yukui Ma
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
Oroxylin A
chronic kidney disease
renal fibrosis
Sirt1
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1499012/full
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