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Single-cell transcriptomics dissects the transcriptome alterations of hematopoietic stem cells in myelodysplastic neoplasms

Abstract Background Myelodysplastic neoplasms (MDS) are myeloid neoplasms characterized by disordered differentiation of hematopoietic stem cells and a predisposition to acute myeloid leukemia (AML). The underline pathogenesis remains unclear. Methods In this study, the trajectory of differentiation...

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Hlavní autoři: Xiangzong Zeng, Yichen Wang, Min Dai, Wei Li, Qingtian Huang, Lingsha Qin, Yuquan Li, Yanwen Yan, Xiangjun Xue, Fang Yi, Wenhao Li, Langyu He, Qifa Liu, Ling Qi
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-04-01
Edice:Journal of Translational Medicine
Témata:
Myelodysplastic neoplasms
Transcriptome alterations
Hematopoietic stem cells
Leukemic transformation
On-line přístup:https://doi.org/10.1186/s12967-024-05165-z
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