Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

Cancer stem cells (CSCs) have been objects of intensive study since their identification in 1994. Adopting a structural rigidification approach, a novel series of 3-phenylthiazolo[3,2-a]benzimidazoles 4a–d was designed and synthesised, in an attempt to develop potent anticancer agent that can target...

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Principais autores:	Ghada H. Al-Ansary, Wagdy M. Eldehna, Hazem A. Ghabbour, Sara T. A. Al-Rashood, Khalid A. Al-Rashood, Radwa A. Eladwy, Abdullah Al-Dhfyan, Maha M. Kabil, Hatem A. Abdel-Aziz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2017-01-01
Colecção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	Cancer stem cells CD133 cytotoxicity colon cancer benzimidazoles X-ray
Acesso em linha:	http://dx.doi.org/10.1080/14756366.2017.1347166
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