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The DMV pore-forming TM2–Y region of SARS-CoV-2 nsp3 exhibits structural conservation beyond the coronavirus family

ABSTRACT Positive-strand RNA viruses remodel host intracellular membranes to form replication organelles in the cytoplasm. SARS-CoV-2 and other coronaviruses, members of the Nidovirales order, replicate within double-membrane vesicles (DMVs) derived from the endoplasmic reticulum that protect newly...

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Autors principals: Alexandra Pozhidaeva, Jeffrey C. Hoch, Yulia Pustovalova
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2026-05-01
Col·lecció:Journal of Virology
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Accés en línia:https://journals.asm.org/doi/10.1128/jvi.02038-25
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