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Molecular Mechanisms of Short-Term Plasticity: Role of Synapsin Phosphorylation in Augmentation and Potentiation of Spontaneous Glutamate Release

We used genetic and pharmacological approaches to identify the signaling pathways involved in augmentation and potentiation, two forms of activity dependent, short-term synaptic plasticity that enhance neurotransmitter release. Trains of presynaptic action potentials produced a robust increase in th...

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Main Authors: Qing Cheng, Sang-Ho Song, George J. Augustine
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
post-tetanic potentiation
synapsins
neurotransmitter release
PKA
synaptic plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00033/full
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